2025 Nfl Season Kicks Off Tonight 2025. The san francisco 49ers are traveling north to take on the seattle. Week 6 of the 2025 nfl season kicks off with a divisional matchup on thursday night.

The 2025 nfl kickoff game will air during a special thursday night edition of sunday night football on nbc, and will stream simultaneously on peacock. 5 with the super bowl champion kansas city chiefs hosting the baltimore ravens.